Short and Novel Stereospecific Synthesis of Trisubstituted 2,5-Diketopiperazines

Steven L. Sollis
Department of Medicinal Chemistry UK, Cardiovascular and Urogenital CEDD, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom
J. Org. Chem., 2005, 70 (12), pp 4735–4740
DOI: 10.1021/jo0501137
Publication Date (Web): May 3, 2005
Copyright © 2005 American Chemical Society

Abstract

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Novel syntheses of chiral trisubstituted 2,5-diketopiperazines using multicomponent Ugi reactions were developed.

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History

  • Published In Issue June 10, 2005
  • Received January 20, 2005

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