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Fluorous Mixture Synthesis of Fused-Tricyclic Hydantoins. Use of a Redundant Tagging Strategy on Fluorinated Substrates
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Abstract
Simple HPLC experiments were used to identify a redundant tagging scheme wherein six different amino acids were tagged with only four fluorous tags. The tagged amino acids were converted to regiosiomeric mixtures of tricyclic hydantoins. Despite the lack of selectivity, the mixtures were demixed and detagged to give 11 individual pure products in just 25 steps.
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This article has been cited by 9 ACS Journal articles (5 most recent appear below).
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Comprehensive Survey of Combinatorial Library Synthesis: 2005
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History
- Published In Issue May 27, 2005
- Received February 8, 2005
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