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Reactions of Enamines with Selectfluor: A Straightforward Route to Difluorinated Carbonyl Compounds

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Weimin Peng and Jean'ne M. Shreeve*

Department of Chemistry, University of Idaho, Moscow, Idaho 83844-2343 jshreeve@uidaho.edu

J. Org. Chem., 2005, 70 (14), pp 5760–5763

DOI: 10.1021/jo0506837

Publication Date (Web): June 2, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Reactions of enamines, preformed from β-dicarbonyl and monocarbonyl compounds, with Selectfluor (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) under mild conditions (triethylamine (TEA) or molecular sieves) easily led to the corresponding difluorinated carbonyl compounds in high yields.

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Published In Issue July 08, 2005
Received April 7, 2005

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Reactions of Enamines with Selectfluor: A Straightforward Route to Difluorinated Carbonyl Compounds

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Recent Highlights in Electrophilic Fluorination with 1-Chloromethyl-4-fluoro- 1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate)

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Novel Palladium-Catalyzed Acyloxylation/Cyclization of 2-(3′-Alkenyl)indoles

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