A Straightforward Synthesis of Ynones by Reaction of Dimethylalkynylaluminum Reagents with Acid Chlorides

Baomin Wang, Martine Bonin, and Laurent Micouin*
Laboratoire de Chimie Thrapeutique, UMR 8638 associe au CNRS et l'Universit Ren Descartes, Facult des Sciences Pharmaceutiques et Biologiques 4, av de l'Observatoire, 75270 Paris Cedex 06, France laurent.micouin@univ-paris5.fr
J. Org. Chem., 2005, 70 (15), pp 6126–6128
DOI: 10.1021/jo050760y
Publication Date (Web): June 22, 2005
Copyright © 2005 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Abstract Image

Alkynyldimethylaluminum reagents react with various aromatic and aliphatic acid chlorides in a fast and efficient way. This reaction provides a simple entry to numerous ynones, using readily available, inexpensive, and nontoxic metalating agent, and does not require any transition metal as a catalyst.

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History

  • Published In Issue July 22, 2005
  • Received April 15, 2005

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