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Synthesis of Benzo[b]furans via CuI-Catalyzed Ring Closure

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Cheng-yi Chen* and Peter G. Dormer

Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065 %cheng_chen@merck.com

J. Org. Chem., 2005, 70 (17), pp 6964–6967

DOI: 10.1021/jo050788+

Publication Date (Web): July 26, 2005

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

A wide variety of benzo[b]furans were synthesized efficiently via a CuI-catalyzed ring closure of 2-haloaromatic ketones. The methodology was tolerant to various functional groups, affording benzofurans in 72−99% yields.

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Published In Issue August 19, 2005
Received April 18, 2005

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Synthesis of Benzo[b]furans via CuI-Catalyzed Ring Closure

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

CuI-Catalyzed Domino Process to 2,3-Disubstituted Benzofurans from 1-Bromo-2-Iodobenzenes and β-Keto Esters

On-Water Chemistry: Copper-Catalyzed Straightforward Synthesis of Benzo[b]furan Derivatives in Neat Water

Mechanistic Studies on the Copper-Catalyzed N-Arylation of Amides

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