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Palladium-Catalyzed One-Pot Synthesis of Highly Substituted Furans by a Three-Component Annulation Reaction

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Xin-hua Duan,^† Xue-yuan Liu,^† Li-na Guo,^† Meng-chun Liao,^† Wei-Min Liu,^‡ and Yong-min Liang*^†^‡

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China, and State Key Laboratory of Solid Lubrication, Lanzhou Institute of Physics, Chinese Academy of Science, Lanzhou 730000, P.R. China liangym@lzu.edu.cn

J. Org. Chem., 2005, 70 (17), pp 6980–6983

DOI: 10.1021/jo050908d

Publication Date (Web): July 19, 2005

†

Lanzhou University.

‡

Chinese Academy of Science.

To whom correspondence should be addressed. Tel: +86-931-8912593. Fax: +86-931-8912582.

Abstract

A new three-component cyclization−coupling reaction catalyzed by palladium was developed, producing polysubstituted furans in good yields from readily available substrates. The reaction conditions and the scope of the process were examined, and a possible mechanism is proposed.

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Published In Issue August 19, 2005
Received May 6, 2005

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Palladium-Catalyzed One-Pot Synthesis of Highly Substituted Furans by a Three-Component Annulation Reaction

Abstract

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History

Recommend & Share

Related Content

2,3,4- or 2,3,5-Trisubstituted Furans: Catalyst-Controlled Highly Regioselective Ring-Opening Cycloisomerization Reaction of Cyclopropenyl Ketones

DABCO-Catalyzed Reaction of α-Halo Carbonyl Compounds with Dimethyl Acetylenedicarboxylate: A Novel Method for the Preparation of Polysubstituted Furans and Highly Functionalized 2H-Pyrans

Synthesis of Highly Substituted Furans by the Electrophile-Induced Coupling of 2-(1-Alkynyl)-2-alken-1-ones and Nucleophiles

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