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Article

Efficient Microwave Access to Polysubstituted Amidines from Imidoylbenzotriazoles

Supporting Info

Alan R. Katritzky,* Chunming Cai, and Sandeep K. Singh

Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200

J. Org. Chem., 2006, 71 (9), pp 3375–3380

DOI: 10.1021/jo052443x

Publication Date (Web): April 5, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, katritzky@chem.ufl.edu

Abstract

Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a−w gave diversely substituted amidines 7a−Aa in 76−94% yields. Convenient preparations of a variety of amides 5a−Ab (87−96%) and imidoylbenzotriazoles 6a−w (56−95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.

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Published In Issue April 28, 2006
Received November 26, 2005

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Article

Efficient Microwave Access to Polysubstituted Amidines from Imidoylbenzotriazoles

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Microwave-Assisted Preparations of Amidrazones and Amidoximes

Synthesis of β-Dicarbonyl Compounds Using 1-Acylbenzotriazoles as Regioselective C-Acylating Reagents

N-Acylbenzotriazoles: Neutral Acylating Reagents for the Preparation of Primary, Secondary, and Tertiary Amides

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