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Cu(II)-Catalyzed Selective Aerobic Oxidation of Alcohols under Mild Conditions

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Nan Jiang and Arthur J. Ragauskas*

Department of Chemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 arthur.ragauskas@chemistry.gatech.edu

J. Org. Chem., 2006, 71 (18), pp 7087–7090

DOI: 10.1021/jo060837y

Publication Date (Web): July 29, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Aerobic Alcohol Oxidation. An efficient four-component system consisting of acetamido-TEMPO/Cu(ClO₄)₂/TMDP/DABCO in DMSO has been developed for room-temperature aerobic alcohol oxidation. Under the optimal conditions, various alcohols could be converted into their corresponding aldehydes or ketones in good to excellent yields. The newly developed catalytic system could also be recycled and reused for three runs without any significant loss of catalytic activity.

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Published In Issue September 01, 2006
Received April 20, 2006

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Cu(II)-Catalyzed Selective Aerobic Oxidation of Alcohols under Mild Conditions