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Article

CoBr₂(Bpy): An Efficient Catalyst for the Direct Conjugate Addition of Aryl Halides or Triflates onto Activated Olefins

Supporting Info

Muriel Amatore, Corinne Gosmini,* and Jacques Périchon

Laboratoire d'Electrochimie, Catalyse et Synthse Organique, UMR 7582, Universit Paris 12-C.N.R.S. 2, rue Henri Dunant, 94320 Thiais, France

J. Org. Chem., 2006, 71 (16), pp 6130–6134

DOI: 10.1021/jo060855f

Publication Date (Web): June 30, 2006

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, gosmini@glvt-cnrs.fr

Abstract

An efficient cobalt-catalyzed method devoted to the direct conjugate addition of functionalized aryl compounds onto Michael acceptors is described. The CoBr₂(2,2‘-bipyridine) complex appears to be an extremely suitable catalyst for the activation of a variety of aromatic reagents ranging from halides to triflates functionalized by reactive groups. This procedure allows for the synthesis of compounds resulting from 1,4-addition in good to excellent yields. The versatility of this original process represents a simple alternative to most known methods using organometallic reagents.

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Published In Issue August 04, 2006
Received April 24, 2006

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Article

CoBr₂(Bpy): An Efficient Catalyst for the Direct Conjugate Addition of Aryl Halides or Triflates onto Activated Olefins