Molecular Iodine-Catalyzed Facile Procedure for N-Boc Protection of Amines

Ravi Varala, Sreelatha Nuvula, and Srinivas R. Adapa*
Indian Institute of Chemical Technology, Hyderabad-500 007, India rvarala_iict@yahoo.co.in
J. Org. Chem., 2006, 71 (21), pp 8283–8286
DOI: 10.1021/jo0612473
Publication Date (Web): September 9, 2006
Copyright © 2006 American Chemical Society
*

 To whom correspondence should be addressed. Phone:  (+91)-40-27193169. Fax:  (+91)-40-27160921.

Abstract

Abstract Image

An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of molecular iodine (10 mol %) under solvent-free conditions at ambient temperature is presented.

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History

  • Published In Issue October 13, 2006
  • Received June 17, 2006

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