Note
Insights into the General and Efficient Cross McMurry Reactions between Ketones
Department of Chemistry, Beijing Normal University, Beijing, 100875, China xinfangduan@vip.163.com
J. Org. Chem., 2006, 71 (26), pp 9873–9876
DOI: 10.1021/jo061644d
Publication Date (Web): November 23, 2006
Copyright © 2006 American Chemical Society
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In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract

The selective cross McMurry couplings of diaryl or aryl ketones with various substituted ketones were achieved in 53−94% isolated yields. It is believed that the strong affinity of the substituents to the low-valent titanium surface plays an important role in regards to moderating selectivity. Through the introduction of such substituents followed by their removal post McMurry coupling, structurally similar ketones can be effectively cross-coupled.
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History
- Published In Issue December 22, 2006
- Received August 7, 2006
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