o-Iodoxybenzoic Acid- and Tetraethylammonium Bromide-Mediated Oxidative Transformation of Primary Carboxamides to One-Carbon Dehomologated Nitriles

Dinesh S. Bhalerao, Ulhas S. Mahajan, Kiran H. Chaudhari, and Krishnacharya G. Akamanchi*
Department of Pharmaceutical Sciences & Technology, University Institute of Chemical Technology, Matunga, Mumbai-400 019, India kgap@rediffmail.com
J. Org. Chem., 2007, 72 (2), pp 662–665
DOI: 10.1021/jo0619074
Publication Date (Web): December 23, 2006
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

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A clean and efficient method for the oxidative transformations of primary carboxamides to one-carbon dehomologated nitriles using the combination of o-iodoxybenzoic acid and tetraethylammonium bromide has been developed. This method exhibits a broad scope and is expected to be of great utility in organic synthesis.

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History

  • Published In Issue January 19, 2007
  • Received September 15, 2006

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