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Synthesis of Symmetrical and Unsymmetrical Pyrazines

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Douglass F. Taber,* Peter W. DeMatteo, and Karen V. Taluskie

Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716 taberdf@udel.edu

J. Org. Chem., 2007, 72 (4), pp 1492–1494

DOI: 10.1021/jo061935m

Publication Date (Web): January 24, 2007

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Opening of representative epoxides with 1,2-amino alcohols delivered the amino diols. The product amino diols were then oxidized under Swern conditions. The amino diketones so prepared were not isolated, but were condensed directly with hydroxylamine to give the substituted pyrazines.

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Published In Issue February 16, 2007
Received September 19, 2006

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Synthesis of Symmetrical and Unsymmetrical Pyrazines

Abstract

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SciFinder Links

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Recommend & Share

Related Content

Facile Regiocontrolled Synthesis of Trialkyl-Substituted Pyrazines

Thieno[3,4-b]pyrazines: Synthesis, Structure, and Reactivity

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