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A Library of Noviosylated Coumarin Analogues
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Section:Abstract
The DNA gyrase inhibitor, novobiocin, was recently shown to inhibit Hsp90 via a previously unrecognized C-terminal ATP-binding site. Previous structure−activity relationship studies identified key moieties that appear important for Hsp90 inhibitory activity. In an effort to provide a more efficacious lead compound, a parallel library of noviosylated coumarin analogues was prepared.
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This article has been cited by 5 ACS Journal articles (5 most recent appear below).
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- Published In Issue May 11, 2007
- Received October 7, 2006
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700 μM in breast cancer cells (SKBr3). Although many analogues of novobiocin have ...
