An Improved Procedure for the Three-Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid

Brindaban C. Ranu,* Ranjan Jana, and S. Sowmiah
Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India ocbcr@iacs.res.in
J. Org. Chem., 2007, 72 (8), pp 3152–3154
DOI: 10.1021/jo070015g
Publication Date (Web): March 17, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Abstract Image

A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions.

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History

  • Published In Issue April 13, 2007
  • Received January 4, 2007

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