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A Facile Approach to the Synthesis of Chiral 2-Substituted Benzofurans

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Lidia De Luca, Giampaolo Giacomelli,* and Giammario Nieddu

Dipartimento di Chimica, Universit degli Studi di Sassari, via Vienna 2, I-07100 Sassari, Italy %ggp@uniss.it

J. Org. Chem., 2007, 72 (10), pp 3955–3957

DOI: 10.1021/jo070142c

Publication Date (Web): April 10, 2007

To whom correspondence should be addressed. Fax: +39-079-212069.

Abstract

An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of α-alkyl-2-benzofuranmethanamines from N-protected α-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.

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Published In Issue May 11, 2007
Received January 24, 2007

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Note

A Facile Approach to the Synthesis of Chiral 2-Substituted Benzofurans

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

CuI-Catalyzed Domino Process to 2,3-Disubstituted Benzofurans from 1-Bromo-2-Iodobenzenes and β-Keto Esters

On-Water Chemistry: Copper-Catalyzed Straightforward Synthesis of Benzo[b]furan Derivatives in Neat Water

Synthesis of Benzo[b]furans via CuI-Catalyzed Ring Closure

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