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A Practical Synthesis of 2,4(5)-Diarylimidazoles from Simple Building Blocks

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Valentina Zuliani,^† Giuseppe Cocconcelli,*^‡ Marco Fantini,^† Chiara Ghiron,^‡ and Mirko Rivara^†

Dipartimento Farmaceutico, Universit degli Studi di Parma, V. le G.P. Usberti, 27/A, I-43100 Parma, Italy and Siena Biotech S.p.A., Via Fiorentina, 1, I-53100 Siena, Italy gcocconcelli@sienabiotech.it

J. Org. Chem., 2007, 72 (12), pp 4551–4553

DOI: 10.1021/jo070187d

Publication Date (Web): May 9, 2007

†

Universitá degli Studi di Parma.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

‡

Siena Biotech S.p.A.

Abstract

A simple and efficient approach to selectively obtain 2,4(5)-diarylimidazoles suppressing formation of 2-aroyl-4(5)-arylimidazoles is described. The yield of each of the two products strongly depends on the reaction conditions employed. This reaction provides a simple method to prepare small libraries of biologically active compounds by parallel synthesis.

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Published In Issue June 08, 2007
Received January 30, 2007

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A Practical Synthesis of 2,4(5)-Diarylimidazoles from Simple Building Blocks

Abstract

Tools

SciFinder Links

History

Recommend & Share

Related Content

Synthesis of Imidazoles through the Copper-Catalyzed Cross-Cycloaddition between Two Different Isocyanides

Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation

Concise Construction of Novel Bridged Bicyclic Lactams by Sequenced Ugi/RCM/Heck Reactions

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