New Catalysts for Suzuki−Miyaura Coupling Reactions of Heteroatom-Substituted Heteroaryl Chlorides

Anil S. Guram,* Xiang Wang, Emilio E. Bunel, Margaret M. Faul, Robert D. Larsen, and Michael J. Martinelli
Chemistry Research and Discovery, Amgen Inc., Thousand Oaks, California 91320-1799
J. Org. Chem., 2007, 72 (14), pp 5104–5112
DOI: 10.1021/jo070341w
Publication Date (Web): June 6, 2007
Copyright © 2007 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

, aguram@amgen.com

Abstract

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The new air-stable PdCl2{PR2(Ph-R‘)}2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki−Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids. The coupling reactions catalyzed by the new complexes exhibit high product yields (88−99%) and high catalyst turnover numbers (up to 10 000 TON).

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History

  • Published In Issue July 06, 2007
  • Received February 19, 2007

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