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Bromination of Deactivated Aromatics: A Simple and Efficient Method

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K. Rajesh, M. Somasundaram, R. Saiganesh,* and K. K. Balasubramanian

Shasun Research Centre, No. 27, Vandaloor-Kelambakkam Road, Keelakottaiyur, Chennai-600 048, India saiganesh@shasun.com

J. Org. Chem., 2007, 72 (15), pp 5867–5869

DOI: 10.1021/jo070477u

Publication Date (Web): June 23, 2007

Section:

Benzene, Its Derivatives, and Condensed Benzenoid Compounds

Abstract

Highly deactivated aromatic compounds were smoothly monobrominated by treatment with N-bromosuccinimide (NBS) in concentrated H₂SO₄ medium affording the corresponding bromo derivatives in good yields. Mild reaction conditions and simple workup provides a practical and commercially viable route for the synthesis of bromo compounds of deactivated aromatics.

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History

Published In Issue July 20, 2007
Received March 7, 2007

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Bromination of Deactivated Aromatics: A Simple and Efficient Method