Note
Diels−Alder Approach to Tetra-ortho-Substituted Biaryls Employing Propargylic Tertiary Alcohols as Dienophiles
In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.
Abstract

The efficient synthesis of a series of tetra-ortho-substituted biaryls is described utilizing a Diels−Alder reaction between propargylic tertiary alcohols and cyclic oxygenated dienes. The successful resolution of one of the biaryls is achieved through derivatization with menthyl chloroformate followed by crystallization. The menthyl carbamate is cleaved under basic conditions to reveal enantiomerically pure biaryl compounds.
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History
- Published In Issue December 21, 2007
- Received April 17, 2007
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