A Simple and Efficient Procedure of Low Valent Iron- or Copper-Mediated Reformatsky Reaction of Aldehydes

Angshuman Chattopadhyay* and Akhil Kr. Dubey
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400 085, India achat@apsara.barc.ernet.in
J. Org. Chem., 2007, 72 (24), pp 9357–9359
DOI: 10.1021/jo0710984
Publication Date (Web): October 31, 2007
Copyright © 2007 American Chemical Society

Abstract

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An operationally simple and very efficient procedure of Reformatsky reaction of aldehydes has been carried out in THF in the presence of low valent iron or copper which were prepared in situ employing a bimetal redox strategy through reduction of FeCl3 or CuCl2−2H2O with magnesium.

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    History

    • Published In Issue November 23, 2007
    • Received May 29, 2007

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