Tandem Bis-aldol Reaction of Ketones:  A Facile One-Pot Synthesis of 1,3-Dioxanes in Aqueous Medium

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Abstract

A novel tandem bis-aldol reaction of ketone with paraformaldehyde catalyzed by polystyrenesulfonic acid in aqueous medium delivers 1,3-dioxanes in high yield. This one-pot, operationally simple microwave-assisted synthetic protocol proceeds efficiently in water in the absence of organic solvent, with excellent yield.

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This article has been cited by 4 ACS Journal articles (4 most recent appear below).

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