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gem-Dibromomethylarenes: A Convenient Substitute for Noncommercial Aldehydes in the Knoevenagel−Doebner Reaction for the Synthesis of α,β-Unsaturated Carboxylic Acids

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John Kallikat Augustine,*^† Yanjerappa Arthoba Naik,^‡ Ashis Baran Mandal,^† Nagaraja Chowdappa,^† and Vinuthan B. Praveen^†

Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3, Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India, and Department of Chemistry, Kuvempu University, Shankaraghatta Post, Shimoga-577 451, India john.kallikat@syngeneintl.com

J. Org. Chem., 2007, 72 (25), pp 9854–9856

DOI: 10.1021/jo701888m

Publication Date (Web): November 14, 2007

Section:

Heterocyclic Compounds (More than One Hetero Atom)

Abstract

A facile synthesis of α,β-unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel−Doebner reaction as aldehyde equivalents for the efficient synthesis of α,β-unsaturated carboxylic acids.

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Published In Issue December 07, 2007
Received September 4, 2007

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gem-Dibromomethylarenes: A Convenient Substitute for Noncommercial Aldehydes in the Knoevenagel−Doebner Reaction for the Synthesis of α,β-Unsaturated Carboxylic Acids

Abstract

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Recommend & Share

Related Content

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An Unusual Reaction of Benzalaminoacetals in Trifluoroacetic Acid: Facile Synthesis of 2-Benzylpyrazines

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