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Facile Access to Polysubstituted Indoles via a Cascade Cu-Catalyzed Arylation−Condensation Process
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Abstract
CuI/l-proline-catalyzed cross-coupling of 2-halotrifluoroacetanilides with β-keto esters and amides followed by in situ acidic hydrolysis delivered 2,3-disubstituted indoles. The halides bearing a strong electron-withdrawing group in the 4-position can undergo in situ basic hydrolysis to provide the corresponding indoles. Polysubstituted indoles can be prepared from substituted 2-halotrifluoroacetanilides with high regioselectivity.
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This article has been cited by 23 ACS Journal articles (5 most recent appear below).
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Juyou Lu and Hua FuThe Journal of Organic Chemistry2011 Article ASAPA convenient and efficient copper-catalyzed cascade method has been developed for synthesis of benzimidazoisoquinoline derivatives via reactions of readily available substituted 2-(2-halophenyl)benzoimidazoles with alkyl cyanoacetates under mild condition,...
Amino Acids as the Nitrogen-Containing Motifs in Copper-Catalyzed Domino Synthesis of N-Heterocycles
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History
- Published In Issue November 23, 2007
- Received September 19, 2007
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