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A New Entry to 1,5-Keto Esters and Their 4,4-Dideuterio Derivatives via Methylene Chloride as “Methylene Dianion” Equivalents
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Abstract

This TiCl4−Mg promoted multicomponent coupling of various amides with CH2Cl2 and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of unusual 4,4-dideuterio-1,5-keto esters.
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A New Entry to 1,5-Keto Esters and Their 4,4-Dideuterio Derivatives via Methylene Chloride as “Methylene Dianion” Equivalents
Kuo-Wei Lin, Cheng-Yih Chen, Wei-Fan Chen and Tu-Hsin YanThe Journal of Organic Chemistry2008 73 (12), 4759-4761A New Entry to 1,5-Keto Esters and Their 4,4-Dideuterio Derivatives via Methylene Chloride as “Methylene Dianion” Equivalents
Kuo-Wei Lin, Cheng-Yih Chen, Wei-Fan Chen and Tu-Hsin YanThe Journal of Organic Chemistry2008 73 (12), 4759-4761This TiCl4−Mg promoted multicomponent coupling of various amides with CH2Cl2 and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of ...
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History
- Published In Issue June 20, 2008
- Article ASAPMay 17, 2008
- Received: April 2, 2008
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