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Birch Reductions at Room Temperature with Alkali Metals in Silica Gel (Na₂K-SG(I))

Supporting Info

Partha Nandi, James L. Dye and James E. Jackson*

Department of Chemistry, Michigan State University, East Lansing, Michigan 48824

J. Org. Chem., 2009, 74 (16), pp 5790–5792

DOI: 10.1021/jo900904f

Publication Date (Web): July 7, 2009

jackson@chemistry.msu.edu

Abstract

Alkali metals in silica gel (the Na₂K-SG(I) reagent) cleanly effect Birch reductions of substrates with at least two or more aromatic rings. The reaction conditions are alcohol-free, ammonia-free, and achieve excellent yields and high selectivities at room temperature.

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History

Published In Issue August 21, 2009
Article ASAPJuly 07, 2009
Received: May 12, 2009

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Birch Reductions at Room Temperature with Alkali Metals in Silica Gel (Na₂K-SG(I))