Preparation of a Stable Trifluoroborate Salt for the Synthesis of 1-Aryl-2,2-difluoro-enolethers and/or 2,2-Difluoro-1-aryl-ketones via Palladium-Mediated Cross-Coupling

Jason D. Katz*, Blair T. Lapointe and Christopher J. Dinsmore
Department of Chemistry, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115
J. Org. Chem., 2009, 74 (22), pp 8866–8869
DOI: 10.1021/jo901789b
Publication Date (Web): October 21, 2009
Copyright © 2009 American Chemical Society

Abstract

Abstract Image

A bench-stable potassium trifluoroborate enol ether reagent has been prepared. This reagent is suitable for the incorporation of 2,2-difluoroenolethers into aryl and heteroaryl systems via palladium-mediated cross-coupling with suitable halide coupling partners.

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History

  • Published In Issue November 20, 2009
  • Article ASAPOctober 21, 2009
  • Received: August 18, 2009

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