Room-Temperature Palladium-Catalyzed Amination of Aryl Bromides and Chlorides and Extended Scope of Aromatic C−N Bond Formation with a Commercial Ligand

John F. Hartwig,* Motoi Kawatsura, Sheila I. Hauck, Kevin H. Shaughnessy, and Luis M. Alcazar-Roman
Department of Chemistry, Yale University P.O. Box 208107, New Haven, Connecticut 06520-8107
J. Org. Chem., 1999, 64 (15), pp 5575–5580
DOI: 10.1021/jo990408i
Publication Date (Web): July 7, 1999
Copyright © 1999 American Chemical Society
*

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Abstract Image

The reactions of aryl bromides with amines occurs at room temperature when using Pd(0) and P(t-Bu)3 in a 1:1 ratio, and the reactions of aryl chlorides occur at room temperature or 70 °C. The arylation of indoles and the new arylation of carbamates also occur when using P(t-Bu)3 as ligand.

Tools

History

  • Published In Issue July 23, 1999
  • Received March 8, 1999

Recommend & Share

Related Content

Other ACS content by these authors: