Article
Room-Temperature Palladium-Catalyzed Amination of Aryl Bromides and Chlorides and Extended Scope of Aromatic C−N Bond Formation with a Commercial Ligand
Department of Chemistry, Yale University P.O. Box 208107, New Haven, Connecticut 06520-8107
J. Org. Chem., 1999, 64 (15), pp 5575–5580
DOI: 10.1021/jo990408i
Publication Date (Web): July 7, 1999
Copyright © 1999 American Chemical Society
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Abstract

The reactions of aryl bromides with amines occurs at room temperature when using Pd(0) and P(t-Bu)3 in a 1:1 ratio, and the reactions of aryl chlorides occur at room temperature or 70 °C. The arylation of indoles and the new arylation of carbamates also occur when using P(t-Bu)3 as ligand.
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History
- Published In Issue July 23, 1999
- Received March 8, 1999
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