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Letter

Resisting the Onset of Hydroxyapatite Dissolution through the Incorporation of Fluoride

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Nora H. de Leeuw^†^‡

School of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, U.K., and Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.

J. Phys. Chem. B, 2004, 108 (6), pp 1809–1811

DOI: 10.1021/jp036784v

Publication Date (Web): January 16, 2004

†

E-mail at Birbeck College: n.deleeuw@mail.cryst.bbk.ac.uk.

‡

E-mail at University College London: n.h.deleeuw@ucl.ac.uk.

Abstract

Molecular dynamics simulations of the incorporation of fluoride into hydroxyapatite show that fluoride ions are easily incorporated from solution into the surface of hydroxyapatite, but although the formation of a fluorapatite film prevents the onset of apatite dissolution, this fluoride does not segregate into the bulk material but remains at the surface. These findings significantly increase our understanding of the role of fluoride in stabilizing hydroxyapatite in tooth enamel and suggest that only repeated exposure to fluoride will have a lasting effect on the tooth enamel structure and its resistance toward dissolution and dental decay.

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History

Published In Issue February 12, 2004
Received September 18, 2003
Revised December 16, 2003

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Letter

Resisting the Onset of Hydroxyapatite Dissolution through the Incorporation of Fluoride