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Resonant ac Dipolar Excitation for Ion Motion Control in the Orbitrap Mass Analyzer

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Qizhi Hu,^† Alexander A. Makarov,^‡ R. Graham Cooks,^† and Robert J. Noll*^†

Chemistry Department, Purdue University, West Lafayette, Indiana 47907, and Thermo Electron (Bremen), Hanna-Kunath-Strasse 11, Bremen 28199 Germany

J. Phys. Chem. A, 2006, 110 (8), pp 2682–2689

DOI: 10.1021/jp054485v

Publication Date (Web): February 8, 2006

Section:

Optical, Electron, and Mass Spectroscopy and Other Related Properties

Abstract

A dipolar ac signal applied to the split outer electrode of an Orbitrap mass spectrometer at the axial resonance frequency causes excitation of ion axial motion and either eventual ion ejection from the trap, if applied in phase with ion motion, or de-excitation, if applied 180° out of phase. Both de-excitation and excitation may be achieved mass-selectively. The extent of ion axial de-excitation depends on the ac amplitude and on the number of cycles applied; sufficient de-excitation can be accomplished such that the ion signal cannot be observed above baseline noise. After de-excitation, the ions remain trapped and in rapid orbital (but not axial) motion, which allows them to be re-excited coherently by application of a second ac waveform allowing the signal again to be observed. Both broad-band and narrow-band waveforms have been used to de-excite and to re-excite ion motion. Using narrow-band waveforms, selective de-excitation and re-excitation can be performed with unit mass selection, leaving an adjacent ¹³C isotopic peak unaffected. The origin and potential applications of these new capabilities is delineated.

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Mass Spectrometry-Based Metabolomics: Accelerating the Characterization of Discriminating Signals by Combining Statistical Correlations and Ultrahigh Resolution
Erwan Werner, Vincent Croixmarie, Thierry Umbdenstock, Eric Ezan, Pierre Chaminade, Jean-Claude Tabet and Christophe Junot
Analytical Chemistry2008 80 (13), 4918-4932
- Mass Spectrometry-Based Metabolomics: Accelerating the Characterization of Discriminating Signals by Combining Statistical Correlations and Ultrahigh Resolution
  Erwan Werner, Vincent Croixmarie, Thierry Umbdenstock, Eric Ezan, Pierre Chaminade, Jean-Claude Tabet and Christophe Junot
  Analytical Chemistry2008 80 (13), 4918-4932
  A strategy combining autocorrelation matrices and ultrahigh resolution mass spectrometry (MS) was developed to optimize the characterization of discriminating ions highlighted by metabolomics. As an example, urine samples from rats treated with ...
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History

Published In Issue March 02, 2006
Received August 10, 2005
Revised December 30, 2005

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Article

Resonant ac Dipolar Excitation for Ion Motion Control in the Orbitrap Mass Analyzer

Abstract

Citing Articles

Mass Spectrometry-Based Metabolomics: Accelerating the Characterization of Discriminating Signals by Combining Statistical Correlations and Ultrahigh Resolution