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Letter

Imaging Pancreatic Cancer Using Surface-Functionalized Quantum Dots

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Jun Qian,^†^‡ Ken-Tye Yong,^† Indrajit Roy,^† Tymish Y. Ohulchanskyy,^† Earl J. Bergey,^† Hoon Hi Lee,^† Kenneth M. Tramposch,^† Sailing He,^‡ Anirban Maitra,^§ and Paras N. Prasad*^†^‡

Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, New York 14260-4200, Centre for Optical and Electromagnetic Research, Zhejiang University, Hangzhou 310058, China, and Department of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, CRB-2, Suite 345, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, Maryland 21231

J. Phys. Chem. B, 2007, 111 (25), pp 6969–6972

DOI: 10.1021/jp070620n

Publication Date (Web): June 7, 2007

Abstract

In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.

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History

Published In Issue June 28, 2007
Received January 24, 2007
Revised March 30, 2007

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Letter

Imaging Pancreatic Cancer Using Surface-Functionalized Quantum Dots

Abstract

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Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging

(CdSe)ZnS Core−Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites

Quantum Rod Bioconjugates as Targeted Probes for Confocal and Two-Photon Fluorescence Imaging of Cancer Cells

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