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Article

Relative Hydrophobicity/Hydrophilicity of Fructose, Glucose, Sucrose, and Trehalose as Probed by 1-Propanol: A Differential Approach in Solution Thermodynamics

Supporting Info

Yoshikata Koga*

Department of Chemistry, The University of British Columbia, and Suitekijuku (Water Drop Institute), Vancouver B. C., Canada V6T 1Z3

Keiko Nishikawa

Graduate School of Advanced Integration Sciences, Chiba University, Chiba, Japan 263-8522

Peter Westh

NSM, Research Unit for Functional Biomaterials, Roskilde University, Roskilde, DK-4000 Denmark

J. Phys. Chem. B, 2007, 111 (50), pp 13943–13948

DOI: 10.1021/jp074273t

Publication Date (Web): November 22, 2007

Corresponding author. E-mail: koga@chem.ubc.ca.

Abstract

Earlier, we developed the 1-propanol probing methodology that could separately evaluate the relative hydrophobicity and hydrophilicity scale of a given sample. We applied it here to fructose, glucose, sucrose, and trehalose and evaluated the same for these saccharides. We then construct a two-dimensional map with the hydrophobicity and the hydrophilicity axes and plot the above saccharides together with other nonelectrolytes subjected earlier to the same analysis. We point out that these saccharides together with other so-called “osmolytes” that accumulate in vivo under H₂O stress occupy a small specific region near H₂O in this map.

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