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Imaging Biological Cells Using Liquid Crystals
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Section:Abstract
Biological cells have been imaged using liquid crystals as an optical amplification medium. Preferential orientation of the liquid-crystal molecules at the surfaces of cells immobilized on substrates leads to well-resolved images, with very sharp contrast compared to images observed by standard phase-contrast microscopy. The feasibility of this technique has been demonstrated for muscle cells, fat cells, and neurons. Calculations based on a continuum elastic theory reproduce the observed features of the images of muscle and fat cells and allow us to estimate the optimum resolution that can be achieved by this technique.
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This article has been cited by 7 ACS Journal articles (5 most recent appear below).
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Boojum and Stripe Textures in Long-Range Orientationally Ordered Monolayers on Solid Substrates
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Wenlang Liang, Tanmay Bera, Xuejun Zhang, Andre J. Gesquiere, and Jiyu FangLangmuir2011 27 (3), 1051-1055Long-range organization of molecular tilt azimuth is a striking feature in monolayers at the air−water interface. We show that the boojum and stripe textures of pentadecanoic acid (PDA) with the continuous variations of molecular tilt azimuth formed at ...
Immobilization of Polymer-Decorated Liquid Crystal Droplets on Chemically Tailored Surfaces
Michael I. Kinsinger, Maren E. Buck, Nicholas L. Abbott and David M. LynnLangmuir2010 26 (12), 10234-10242Immobilization of Polymer-Decorated Liquid Crystal Droplets on Chemically Tailored Surfaces
Michael I. Kinsinger, Maren E. Buck, Nicholas L. Abbott and David M. LynnLangmuir2010 26 (12), 10234-10242We demonstrate that the assembly of an amphiphilic polyamine on the interfaces of micrometer-sized droplets of a thermotropic liquid crystal (LC) dispersed in aqueous solutions can be used to facilitate the immobilization of LC droplets on chemically ...
Measurement of the Azimuthal Anchoring Energy of Liquid Crystals in Contact with Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers Supported on Obliquely Deposited Gold Films
Brian H. Clare, Orlando Guzmán, Juan J. de Pablo, and Nicholas L. AbbottLangmuir2006 22 (10), 4654-4659Measurement of the Azimuthal Anchoring Energy of Liquid Crystals in Contact with Oligo(ethylene glycol)-Terminated Self-Assembled Monolayers Supported on Obliquely Deposited Gold Films
Brian H. Clare, Orlando Guzmán, Juan J. de Pablo, and Nicholas L. AbbottLangmuir2006 22 (10), 4654-4659We report measurements of the orientations and azimuthal anchoring energies of the nematic liquid crystal 4-cyano-4‘-pentylbiphenyl (5CB) on polycrystalline gold films that are deposited from a vapor at an oblique angle of incidence and subsequently ...
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History
- Published In Issue April 01, 2003
- Received August 14, 2002
Revised October 10, 2002
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