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Research Article

Photochemical Functionalization of Polymer Surfaces for Microfabricated Devices

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Justin S. Mecomber,^† Rajesh S. Murthy,^‡ Sridhar Rajam,^‡ Pradeep N. D. Singh,^‡ Anna D. Gudmundsdottir,*^‡ and Patrick A. Limbach*^†

Department of Chemistry and Rieveschl Laboratories for Mass Spectrometry, University of Cincinnati, Cincinnati, Ohio 45221

Langmuir, 2008, 24 (7), pp 3645–3653

DOI: 10.1021/la7033577

Publication Date (Web): February 23, 2008

Abstract

Herein we report the topochemical modification of polymer surfaces with perfluorinated aromatic azides. The aryl azides, which have quaternary amine or aldehyde functional groups, were linked to the surface of the polymer by UV irradiation. The polymer substrates used in this study were cyclic olefin copolymer and poly(methyl methacrylate). These substrates were characterized before and after modification using reflection−absorption infrared spectroscopy, sessile water contact angle measurements, and X-ray photoelectron spectroscopy. Analysis of the surface confirmed the presence of aromatic groups with aldehyde or quaternary amine functionality. Enzyme immobilization and patterning onto polymer surfaces were studied using confocal microscopy. Enzymatic digests of protein were carried out on modified probes manufactured from thermoplastic substrates, and the resulting peptide analysis was completed using matrix-assisted laser desorption/ionization mass spectrometry. The use of functionalized perfluorinated aromatic azides allows the surface chemistry of thermoplastics to be tailored for specific lab-on-a-chip applications.

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Efficient Immobilization and Patterning of Biomolecules on Poly(ethylene terephthalate) Films Functionalized by Ion Irradiation for Biosensor Applications
In-Tae Hwang, In-Seol Kuk, Chan-Hee Jung, Jae-Hak Choi, Young-Chang Nho, and Young-Moo Lee
ACS Applied Materials & Interfaces2011 3 (7), 2235-2239
- Efficient Immobilization and Patterning of Biomolecules on Poly(ethylene terephthalate) Films Functionalized by Ion Irradiation for Biosensor Applications
  In-Tae Hwang, In-Seol Kuk, Chan-Hee Jung, Jae-Hak Choi, Young-Chang Nho, and Young-Moo Lee
  ACS Applied Materials & Interfaces2011 3 (7), 2235-2239
  The surface of a poly(ethylene terephthalate) (PET) film was selectively irradiated with proton beams at various fluences to generate carboxylic acid groups on the surface; the resulting functionalized PET surface was then characterized in terms of its ...
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