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Biomolecular Recognition Based on Single Gold Nanoparticle Light Scattering

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G. Raschke,* S. Kowarik, T. Franzl, C. Sönnichsen,^† T. A. Klar, and J. Feldmann

Photonics and Optoelectronics Group, Department of Physics and CeNS, Ludwig-Maximilians-Universität, Amalienstr. 54, D-80799 Munich, Germany

A. Nichtl and K. Kürzinger

Roche Diagnostics GmbH, Nonnenwald 2, D-82372 Penzberg, Germany

Nano Letters, 2003, 3 (7), pp 935–938

DOI: 10.1021/nl034223+

Publication Date (Web): May 30, 2003

Section:

Biochemical Methods

Abstract

A method for biomolecular recognition is reported using light scattering of a single gold nanoparticle functionalized with biotin. Addition of streptavidin and subsequent specific binding events alter the dielectric environment of the nanoparticle, resulting in a spectral shift of the particle plasmon resonance. As we use single nanoparticles showing a homogeneous scattering spectrum, spectral shifts as small as 2 meV can be detected.

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