Glucose Biosensors Based on Carbon Nanotube Nanoelectrode Ensembles

Yuehe Lin,*† Fang Lu,† Yi Tu,‡ and Zhifeng Ren‡
Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99352, and Boston College, Chestnut Hill, Massachusetts 02467
Nano Letters, 2004, 4 (2), pp 191–195
DOI: 10.1021/nl0347233
Publication Date (Web): December 20, 2003
Copyright © 2004 American Chemical Society

Abstract

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This paper describes the development of glucose biosensors based on carbon nanotube (CNT) nanoelectrode ensembles (NEEs) for the selective detection of glucose. Glucose oxidase was covalently immobilized on CNT NEEs via carbodiimide chemistry by forming amide linkages between their amine residues and carboxylic acid groups on the CNT tips. The catalytic reduction of hydrogen peroxide liberated from the enzymatic reaction of glucose oxidase upon the glucose and oxygen on CNT NEEs leads to the selective detection of glucose. The biosensor effectively performs a selective electrochemical analysis of glucose in the presence of common interferents (e.g., acetaminophen, uric and ascorbic acids), avoiding the generation of an overlapping signal from such interferers. Such an operation eliminates the need for permselective membrane barriers or artificial electron mediators, thus greatly simplifying the sensor design and fabrication.

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History

  • Published In Issue February 11, 2004
  • Received August 29, 2003
    Revised Manuscript Received December 1, 2003

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