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Designed Dendrimer Syntheses by Self-Assembly of Single-Site, ssDNA Functionalized Dendrons

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Cordell R. DeMattei,^† Baohua Huang,^† and Donald A. Tomalia*^†^‡

Dendritic NanoTechnologies, Inc., Central Michigan University, 2625 Denison Drive, Mt. Pleasant, Michigan 48858

Nano Letters, 2004, 4 (5), pp 771–777

DOI: 10.1021/nl034957m

Publication Date (Web): April 13, 2004

Section:

General Biochemistry

Abstract

Single site, functionalized, single stranded (ssDNA) dendri-poly(amidoamine) (PAMAM) di-dendrons have been synthesized by covalently conjugating complementary 32 base pair oligonucleotides to single-site, thiol functionalized dendri-PAMAM di-dendrons possessing neutral or anionic surface groups. Combining these complementary (ss-DNA) functionalized PAMAM di-dendrons at appropriate assembly temperatures produced Watson−Crick base paired (dsDNA) cores, surrounded by four PAMAM dendrons. These novel core−shell nanostructures represent a new class of precise monodisperse, linear-dendritic architectural copolymers. Using comparative gel electrophoresis, it was demonstrated that these self-assembled (di-dendron) dendrimers could be hemispherically differentiated as a function of surface chemistry as well as generational size. This new supramacromolecular approach offers a very facile and versatile strategy for the combinatorial design of size, shape, and surface substituents for both homogeneous and differentiated dendritic nanostructures.

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This article has been cited by 15 ACS Journal articles (5 most recent appear below).

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