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Abstract

A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.

Citing Articles

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This article has been cited by 52 ACS Journal articles (5 most recent appear below).

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  Relaxometric Studies of γ-Fe₂O₃@SiO₂ Core Shell Nanoparticles: When the Coating Matters

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  The Journal of Physical Chemistry C2012 116 (3), 2285-2291

  • Relaxometric Studies of γ-Fe₂O₃@SiO₂ Core Shell Nanoparticles: When the Coating Matters

    Sonia L. C. Pinho, Sophie Laurent, João Rocha, Alain Roch, Marie-Hélène Delville, Stéphane Mornet, Luis D. Carlos, Luce Vander Elst, Robert N. Muller, and Carlos F. G. C. Geraldes
    The Journal of Physical Chemistry C2012 116 (3), 2285-2291

    Iron oxide nanoparticles with a constant superparamagnetic core coated with a silica shell with a thickness ranging from 0.6 to 71 nm were prepared by a fast and facile soft chemistry approach. The increase of the coating thickness of the γ-Fe2O3@SiO2 ...

    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
• 

  Towards Brighter Hybrid Magnetic-Luminescent Nanoparticles: Luminosity Dependence on Excited State Properties of Embedded Dyes

  Arnold Jason Kell , Michael L Barnes , Zygmunt J. Jakubek , and Benoit Simard
  The Journal of Physical Chemistry C 0 (ja),

  • Towards Brighter Hybrid Magnetic-Luminescent Nanoparticles: Luminosity Dependence on Excited State Properties of Embedded Dyes

    Arnold Jason Kell , Michael L Barnes , Zygmunt J. Jakubek , and Benoit Simard
    The Journal of Physical Chemistry C 0 (ja),

    Abstract A series of hybrid, magnetic and luminescent silica nanoparticles (SNP) have been synthesized and their photophysical properties characterized. The nanoparticles contain, on average, one iron oxide nanoparticle as a magnetic core. The embedded ...

    Abstract | Hi-Res PDF | PDF w/ Links
• 

  Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells

  Luis J. Cruz, Paul J. Tacken, Fernando Bonetto, Sonja I. Buschow, Huib J. Croes, Mietske Wijers, I. Jolanda de Vries, and Carl G. Figdor
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  • Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells

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    Dendritic cells (DCs) are key players in the initiation of adaptive immune responses and are currently exploited in immunotherapy against cancer and infectious diseases. The targeted delivery of nanovaccine particles (NPs) to DCs in vivo is a promising ...

    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
• 

  Clustered Magnetite Nanocrystals Cross-Linked with PEI for Efficient siRNA Delivery

  Ji Won Park, Ki Hyun Bae, Chunsoo Kim, and Tae Gwan Park
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    Biomacromolecules2011 12 (2), 457-465

    Magnetofection has been utilized as a powerful tool to enhance gene transfection efficiency via magnetic field-enforced cellular transport processes. The accelerated accumulation of nucleic acid molecules by applying an external magnetic force enables the ...

    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
• 

  Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy

  Muharrem Akcan, Mark R. Stroud, Stacey J. Hansen, Richard J. Clark, Norelle L. Daly, David J. Craik, and James M. Olson
  Journal of Medicinal Chemistry2011 54 (3), 782-787

  • Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy

    Muharrem Akcan, Mark R. Stroud, Stacey J. Hansen, Richard J. Clark, Norelle L. Daly, David J. Craik, and James M. Olson
    Journal of Medicinal Chemistry2011 54 (3), 782-787

    Bioconjugates composed of chlorotoxin and near-infrared fluorescent (NIRF) moieties are being advanced toward human clinical trials as intraoperative imaging agents that will enable surgeons to visualize small foci of cancer. In previous studies, the NIRF ...

    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links

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