DNA Translocation in Inorganic Nanotubes

Rong Fan,† Rohit Karnik,‡ Min Yue,‡ Deyu Li,‡ Arun Majumdar,*‡§ and Peidong Yang*†§
Department of Chemistry, University of California, Berkeley, California 94720, Department of Mechanical Engineering, University of California, Berkeley, California 94720, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720
Nano Lett., 2005, 5 (9), pp 1633–1637
DOI: 10.1021/nl0509677
Publication Date (Web): June 28, 2005
Copyright © 2005 American Chemical Society

Abstract

Abstract Image

Inorganic nanotubes were successfully integrated with microfluidic systems to create nanofluidic devices for single DNA molecule sensing. Inorganic nanotubes are unique in their high aspect ratio and exhibit translocation characteristics in which the DNA is fully stretched. Transient changes of ionic current indicate DNA translocation events. A transition from current decrease to current enhancement during translocation was observed on changing the buffer concentration, suggesting interplay between electrostatic charge and geometric blockage effects. These inorganic nanotube nanofluidic devices represent a new platform for the study of single biomolecule translocation with the potential for integration into nanofluidic circuits.

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History

  • Published In Issue September 14, 2005
  • Received May 23, 2005
    Revised Manuscript Received June 14, 2005

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