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Letter

Nanotechnology-Based Photodynamic Therapy for Neovascular Disease Using a Supramolecular Nanocarrier Loaded with a Dendritic Photosensitizer

Ryuichi Ideta,^†^‡ Fumitaka Tasaka,^†^‡ Woo-Dong Jang,^†^§ Nobuhiro Nishiyama, Guo-Dong Zhang,^§ Atsushi Harada, Yasuo Yanagi,^‡ Yasuhiro Tamaki,^‡ Takuzo Aida,^# and Kazunori Kataoka*^§

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Center for Disease Biology and Investigative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Department of Applied Materials Science, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan, Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, and Research & Development Division, Santen Pharmaceutical Co., Ltd., 8916-16 Takayama-cho, Ikoma, Nara 630-0101, Japan

Nano Lett., 2005, 5 (12), pp 2426–2431

DOI: 10.1021/nl051679d

Publication Date (Web): October 27, 2005

†

Equally contributed to this work.

‡

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo.

Santen Pharmaceutical Co., Ltd.

Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo.

Center for Disease Biology and Investigative Medicine, Graduate School of Medicine, The University of Tokyo.

Osaka Prefecture University.

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo.

Corresponding author. Address: Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Fax +81-3-5841-7139. Tel +81-3-5841-7138. E-mail; kataoka@bmw.t.u-tokyo.ac.jp.

Abstract

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensitizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

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