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Letter

Antibody Molecules Discriminate between Crystalline Facets of a Gallium Arsenide Semiconductor

Supporting Info

Arbel Artzy Schnirman,^†^‡ Efrat Zahavi,^† Hadas Yeger,^‡^§ Ronit Rosenfeld, Itai Benhar, Yoram Reiter,^†^‡ and Uri Sivan*^‡^§

Department of Biology, Department of Physics, and The Russell Berrie Nanotechnology Institute, TechnionIsrael Institute of Technology, Haifa 32000, Israel, and G. S. Wise Faculty of Life Sciences, Department of Molecular Microbiology & Biotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel

Nano Lett., 2006, 6 (9), pp 1870–1874

DOI: 10.1021/nl0607636

Publication Date (Web): August 3, 2006

†

Department of Biology, TechnionIsrael Institute of Technology.

‡

The Russell Berrie Nanotechnology Institute, TechnionIsrael Institute of Technology.

Department of Physics, TechnionIsrael Institute of Technology.

G. S. Wise Faculty of Life Sciences, Department of Molecular Microbiology & Biotechnology, Tel Aviv University.

In papers with more than one author, the asterisk indicates the name of the author to whom inquiries about the paper should be addressed.

Abstract

Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In the following we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed to generate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs (111A) facets as opposed to GaAs (100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on (111A) surfaces in a structure comprising a mixture of (100) and (111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vis published experiments with short and longer peptides.

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