Heparin Binding Nanostructures to Promote Growth of Blood Vessels

Kanya Rajangam,† Heather A. Behanna,‡ Michael J. Hui,† Xiaoqiang Han,§ James F. Hulvat, Jon W. Lomasney,§ and Samuel I. Stupp*‡
Department of Biomedical Engineering, Department of Chemistry, Department of Pathology, Institute for BioNanotechnology in Medicine, Department of Materials Science and Engineering, and Department of Medicine, Northwestern University, Evanston, Illinois 60208
Nano Lett., 2006, 6 (9), pp 2086–2090
DOI: 10.1021/nl0613555
Publication Date (Web): August 3, 2006
Copyright © 2006 American Chemical Society
†

 Department of Biomedical Engineering.

,
‡

 Department of Chemistry.

,
§

 Department of Pathology.

,

 Institute for BioNanotechnology in Medicine.

,

 Department of Materials Science and Engineering.

,
*

 Corresponding author. E-mail:  s-stupp@northwestern.edu.

Abstract

Abstract Image

Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue September 13, 2006
  • Received June 12, 2006
    Revised Manuscript Received July 25, 2006

Recommend & Share

Related Content

Other ACS content by these authors: