Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems

Norased Nasongkla,† Erik Bey,† Jimin Ren,‡ Hua Ai,† Chalermchai Khemtong,† Jagadeesh Setti Guthi,† Shook-Fong Chin,† A. Dean Sherry,‡ David A. Boothman,† and Jinming Gao*†
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, and Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390
Nano Lett., 2006, 6 (11), pp 2427–2430
DOI: 10.1021/nl061412u
Publication Date (Web): October 24, 2006
Copyright © 2006 American Chemical Society
†

 Simmons Comprehensive Cancer Center.

,
‡

 Advanced Imaging Research Center.

,
*

 Corresponding author. E-mail:  jinming.gao@utsouthwestern.edu. Phone:  (+1) 214-648-9278. Fax:  (+1) 214-648-0264.

Abstract

Abstract Image

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via αvβ3 integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to αvβ3-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and αvβ3-specific cytotoxic response of these multifunctional polymeric micelles.

View: Full Text HTML | Hi-Res PDF

Tools

History

  • Published In Issue November 08, 2006
  • Received June 20, 2006
    Revised Manuscript Received October 5, 2006

Recommend & Share

Related Content

Other ACS content by these authors: