Effects of Mechanical Flexion on the Penetration of Fullerene Amino Acid-Derivatized Peptide Nanoparticles through Skin

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Abstract

Dermatomed porcine skin was fixed to a flexing device and topically dosed with 33.5 mg·mL^-1 of an aqueous solution of a fullerene-substituted phenylalanine (Baa) derivative of a nuclear localization peptide sequence (Baa-Lys(FITC)-NLS). Skin was flexed for 60 or 90 min or left unflexed (control). Confocal microscopy depicted dermal penetration of the nanoparticles at 8 h in skin flexed for 60 and 90 min, whereas Baa-Lys(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h. TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum.

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This article has been cited by 6 ACS Journal articles (5 most recent appear below).

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    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
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  Theoretical Study on the Chiroptical Optical Properties of Chiral Fullerene C₆₀ Derivative

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    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
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  Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca²⁺ Influx Sensitive to Calcium Entry Inhibitors

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• 

  Aziridination of C₆₀ with Simple Amides and Catalytic Rearrangement of the Aziridinofullerenes to Azafulleroids

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    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
• 

  In Vivo Skin Penetration of Quantum Dot Nanoparticles in the Murine Model: The Effect of UVR

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    Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links

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