Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer

Tymish Y. Ohulchanskyy,† Indrajit Roy,† Lalit N. Goswami,†‡ Yihui Chen,‡ Earl J. Bergey,† Ravindra K. Pandey,*†‡ Allan R. Oseroff,*‡ and Paras N. Prasad*†
Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York, and PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York
Nano Lett., 2007, 7 (9), pp 2835–2842
DOI: 10.1021/nl0714637
Publication Date (Web): August 25, 2007
Copyright © 2007 American Chemical Society
†

 Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York.

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‡

 PDT Center, Cell Stress Biology, Roswell Park Cancer Institute.

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*

 Corresponding authors. E-mail:  ravindra.pandey@roswellpark.org (R.K.P.); Allan.Oseroff@RoswellPark.org (A.R.O.); pnprasad@buffalo.edu (P.N.P.).

Abstract

Abstract Image

We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size (20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.

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History

  • Published In Issue September 12, 2007
  • Received June 19, 2007
    Revised Manuscript Received August 9, 2007

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