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Letter

Direct Electrical Measurements on Single-Molecule Genomic DNA Using Single-Walled Carbon Nanotubes

Supporting Info

Somenath Roy,^† Harindra Vedala,^† Aparna Datta Roy,^† Do-hyun Kim,^† Melissa Doud,^‡ Kalai Mathee,^‡ Hoon-kyu Shin,^£ Nobuo Shimamoto,^§ Viswanath Prasad,^† and Wonbong Choi*^†

Department of Mechanical and Materials Engineering, Florida International University, Miami, Florida 33174, Department of Biological Sciences, Florida International University, Miami, Florida 33199, National Center for Nanomaterials Technology, Pohang University of Science and Technology, Pohang 790-784, Korea, and National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan

Nano Lett., 2008, 8 (1), pp 26–30

DOI: 10.1021/nl0716451

Publication Date (Web): December 1, 2007

†

Department of Mechanical and Materials Engineering, Florida International University.

‡

Department of Biological Sciences, Florida International University.

Pohang University of Science and Technology.

National Institute of Genetics.

To whom correspondence should be addressed. E-mail: choiw@fiu.edu.

Abstract

A unique nanoelectronic platform, based on single-walled carbon nanotubes (SWNTs), has been fabricated for measuring electrical transport in single-molecule DNA. We have tested 80 base pairs of single- and double-stranded DNA (ssDNA and dsDNA, respectively) of complex base sequences. About a 25−40 pA current (at 1 V) was measured for the dsDNA molecule covalently attached to the SWNT electrode at its termini. In the absence of base pair stacking, a ssDNA carries a feeble current of 1 pA or less. Gate-voltage-dependent I−V characteristics revealed that the bridging dsDNA molecule acts as a p-type channel between SWNT source and drain electrodes.