Modeling the Thermodynamics of the Interaction of Nanoparticles with Cell Membranes

Valeriy V. Ginzburg* and Sudhakar Balijepalli
Research and Development, The Dow Chemical Company, Building 1710, Midland, Michigan 48674
Nano Lett., 2007, 7 (12), pp 3716–3722
DOI: 10.1021/nl072053l
Publication Date (Web): November 6, 2007
Copyright © 2007 American Chemical Society
*

 To whom the correspondence should be addressed. Email:  vvginzburg@dow.com. Ph:  (989) 636-9565.

Abstract

Abstract Image

Interactions between nanoparticles and cell membranes may play a crucial role in determining the cytotoxicity of nanoparticles as well as their potential application as drug delivery vehicles or therapeutic agents. It has been shown that such interactions are often determined not by biochemical but by physicochemical factors (e.g., nanoparticle size, hydrophobicity, and surface charge density). Here, we propose a mesoscale thermodynamic model describing the transitions in membrane morphology observed after exposure to various types of nanoparticles. Our simulations demonstrate under which conditions (determined by particle size and hydrophilic/hydrophobic interactions) the particles can adsorb into the membrane or compromise the membrane integrity to result in the formation of nanosized holes. The model could be refined to include a more accurate description of various phospholipid membranes, and its results could be applied in the design of specific nanoparticles for various biomedical applications.

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History

  • Published In Issue December 12, 2007
  • Received August 15, 2007
    Revised Manuscript Received October 18, 2007

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