Noninvasive Raman Spectroscopy in Living Mice for Evaluation of Tumor Targeting with Carbon Nanotubes

C. Zavaleta†, A. de la Zerda†, Z. Liu‡, S. Keren†, Z. Cheng†, M. Schipper†, X. Chen†, H. Dai‡ and S. S. Gambhir*†
Molecular Imaging Program at Stanford, Departments of Radiology and Bioengineering, Bio-X Program, Stanford University, 1201 Welch Road, Stanford, California 94305-5484, and Department of Chemistry, Stanford University, Stanford, California 94305
Nano Lett., 2008, 8 (9), pp 2800–2805
DOI: 10.1021/nl801362a
Publication Date (Web): August 7, 2008
Copyright © 2008 American Chemical Society
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Departments of Radiology and Bioengineering, Bio-X Program, Stanford University.

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‡

Department of Chemistry, Stanford University.

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* To whom correspondence should be addressed: Phone: 650-725-2309. Fax: 650-724-4948. E-mail: sgambhir@stanford.edu.

Abstract

Abstract Image

An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor (p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.

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History

  • Published In Issue September 10, 2008
  • Article ASAPAugust 07, 2008
  • Received: May 12, 2008
    Revised: June 27, 2008

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