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Mass Spectrometry of Self-Assembled Monolayers: A New Tool for Molecular Surface Science
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Section:Abstract
Most reactions can be performed in solution and on a surface, yet the challenges faced in applying known reactions or in developing entirely new reactions for modifying surfaces remain formidable. The products of many reactions performed in solution can be characterized in minutes, and even products having complex structures can be characterized in hours. When performed on surfaces, even the most basic reactions require a substantial effort—requiring several weeks—to characterize the yields and structures of the products. This contrast stems from the lack of convenient analytical tools that provide rapid information on the structures of molecules attached to a surface. This review describes recent work that has established mass spectrometry as a powerful method for developing and characterizing a broad range of chemical reactions of molecules attached to self-assembled monolayers of alkanethiolates on gold. The SAMDI-TOF mass spectrometry technique will enable a next generation of applications of molecularly defined surfaces to problems in chemistry and biology.
Keywords:
biochip; interfacial reactions; label-free; self-assembled monolayer; SAMDI-TOF mass spectrometryCiting Articles
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This article has been cited by 21 ACS Journal articles (5 most recent appear below).
Comparison of Oligo(ethylene glycol)alkanethiols versus n-Alkanethiols: Self-Assembly, Insertion, and Functionalization
Mitchell J. Shuster, Amit Vaish, Megan L. Gilbert, Michelle Martinez-Rivera, Roya M. Nezarati, Paul S. Weiss, and Anne M. AndrewsThe Journal of Physical Chemistry C2011 115 (50), 24778-24787Comparison of Oligo(ethylene glycol)alkanethiols versus n-Alkanethiols: Self-Assembly, Insertion, and Functionalization
Mitchell J. Shuster, Amit Vaish, Megan L. Gilbert, Michelle Martinez-Rivera, Roya M. Nezarati, Paul S. Weiss, and Anne M. AndrewsThe Journal of Physical Chemistry C2011 115 (50), 24778-24787We describe the self-assembly and chemical functionalization of oligo(ethylene glycol)alkanethiol (OEG) molecules. Insertion of OEGs into n-alkanethiolate monolayer matrices depends considerably on terminal functionality, unlike insertion of n-...
Hydrogen Peroxide-Induced Oxidation of Mixtures of Alkanethiols and Their Quantitative Detection as Alkanesulfonates by Electrospray Ionization Mass Spectrometry
Rachel Roberts, Joshua A. Driver, Danielle M. Brown, Sagar H. Amin, and Brian W. GregoryAnalytical Chemistry2011 83 (24), 9605-9613Hydrogen Peroxide-Induced Oxidation of Mixtures of Alkanethiols and Their Quantitative Detection as Alkanesulfonates by Electrospray Ionization Mass Spectrometry
Rachel Roberts, Joshua A. Driver, Danielle M. Brown, Sagar H. Amin, and Brian W. GregoryAnalytical Chemistry2011 83 (24), 9605-9613Finding optimal experimental conditions for generating stable negative ion electrospray ionization ion trap mass spectra (ESI-IT-MS) of alkanethiol-derived species is critical for quantitatively characterizing multicomponent alkanethiol-based self-...
Rapid Characterization of Protein Chips Using Microwave-Assisted Protein Tryptic Digestion and MALDI Mass Spectrometry
Na Young Ha, Shin Hye Kim, Tae Geol Lee, and Sang Yun HanLangmuir2011 27 (16), 10098-10105Rapid Characterization of Protein Chips Using Microwave-Assisted Protein Tryptic Digestion and MALDI Mass Spectrometry
Na Young Ha, Shin Hye Kim, Tae Geol Lee, and Sang Yun HanLangmuir2011 27 (16), 10098-10105We demonstrate that the microwave-assisted protein enzymatic digestion (MAPED) method can be successfully applied to the mass spectrometric characterization of proteins captured on the affinity surfaces of protein chips. The microwave-assisted on-chip ...
High-Throughput Screening of Small Molecule Libraries using SAMDI Mass Spectrometry
Zachary A. Gurard-Levin, Michael D. Scholle, Adam H. Eisenberg, and Milan MrksichACS Combinatorial Science2011 13 (4), 347-350High-Throughput Screening of Small Molecule Libraries using SAMDI Mass Spectrometry
Zachary A. Gurard-Levin, Michael D. Scholle, Adam H. Eisenberg, and Milan MrksichACS Combinatorial Science2011 13 (4), 347-350High-throughput screening is a common strategy used to identify compounds that modulate biochemical activities, but many approaches depend on cumbersome fluorescent reporters or antibodies and often produce false-positive hits. The development of “label-...
Direct Patterning of Silanized-Biomolecules on Semiconductor Surfaces
Dorjderem Nyamjav and Richard C. HolzLangmuir2010 26 (23), 18300-18302Direct Patterning of Silanized-Biomolecules on Semiconductor Surfaces
Dorjderem Nyamjav and Richard C. HolzLangmuir2010 26 (23), 18300-18302A novel approach to pattern silanized-biomolecules directly onto glass (SiOx) substrates via Dip-Pen nanolithography (DPN) and microcontact printing (μCP) is presented. Subsequent hybridization reactions of DPN patterned silanized-DNA with its ...
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History
- Published In Issue January 22, 2008
- Article ASAPJanuary 22, 2008
- Received: December 10, 2007
Accepted: December 17, 2007
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