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Perspectives

Adenovirus in a Synthetic Membrane Wrapper: An Example of Hybrid Vigor?

Even though more than two decades have passed since the first report of lipofection, there is still a compelling need for the development of new vector approaches to realize the enormous potential of this field.

There are no non-viral systems that are anywhere close to achieving the same level of sophisticated functional integration into their design as viruses.

Any effective nucleic acid carrier system will ultimately need to address the issues of safe manufacture in large volumes, with reproducible production and shelf stability, and at low cost before gaining clinical acceptance.

The most pressing needs for the development of efficient non-viral carrier systems are improvements in targeting efficiency and selectivity.

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David H. Thompson*

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907

ACS Nano, 2008, 2 (5), pp 821–826

DOI: 10.1021/nn800279s

Publication Date (Web): May 27, 2008

* Address correspondence to davethom@purdue.edu.

Abstract

Nucleic acid delivery applications require the development of carrier systems that are effective, selective, and non-toxic. Many different viral and non-viral approaches, including the use of retroviruses, adenoviruses, liposomes, and dendrimers, have been investigated. Unfortunately, issues still remain with regard to the safety and efficiency of these delivery vehicles. In this Perspective, the challenges of designing a stable vector that is capable of effective gene therapy are highlighted. Progress in the area is also presented, including the work of Kostarelos and co-workers appearing in this issue of ACS Nano, in which they describe a novel delivery vehicle that consists of lipid envelopes encasing viral nanoparticles.

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This article has been cited by 2 ACS Journal articles (2 most recent appear below).

Formation and Finite Element Analysis of Tethered Bilayer Lipid Structures
Kwang Joo Kwak, Gintaras Valincius, Wei-Ching Liao, Xin Hu, Xuejin Wen, Andrew Lee, Bo Yu, David J. Vanderah, Wu Lu, and L. James Lee
Langmuir2010 26 (23), 18199-18208
- Formation and Finite Element Analysis of Tethered Bilayer Lipid Structures
  Kwang Joo Kwak, Gintaras Valincius, Wei-Ching Liao, Xin Hu, Xuejin Wen, Andrew Lee, Bo Yu, David J. Vanderah, Wu Lu, and L. James Lee
  Langmuir2010 26 (23), 18199-18208
  Rapid solvent exchange of an ethanolic solution of diphytanoyl phosphatidylcholine (DPhyPC) in the presence of a mixed self-assembled monolayer (SAM) [thiolipid/β-mercaptoethanol (βME) (3/7 mol/mol) on Au] shows a transition from densely packed tethered ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Cationic Glyconanoparticles: Their Complexation with DNA, Cellular Uptake, and Transfection Efficiencies
Marya Ahmed, Zhicheng Deng, Shiyong Liu, Robert Lafrenie, Aseem Kumar and Ravin Narain
Bioconjugate Chemistry2009 20 (11), 2169-2176
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  Marya Ahmed, Zhicheng Deng, Shiyong Liu, Robert Lafrenie, Aseem Kumar and Ravin Narain
  Bioconjugate Chemistry2009 20 (11), 2169-2176
  There is a need to synthesize new gene delivery vehicles that can deal with the problems of endosomal escape and nuclear entry. We propose cationic glycopolymer-stabilized gold nanoparticles as an effective gene delivery system. The cationic ...
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